Adrenocorticotropic hormone fragment4-10 human

Not available outside of the UK & Ireland.

Amino Acid Sequence

Met-Glu-His-Phe-Arg-Trp-Gly

Biochem/physiol Actions

Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.

Other Notes

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Quality

Lacks adrenocorticotropic activity.