Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
TG003 has been used to develop assays for screening substances that affect mRNA splicing1.
TG003 has been used in PAC1 cell culture and in vitro kinase assays.
Biochem/physiol Actions
TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.
TG003 regulates alternative splicing and reduces the phosphorylation of SF2/ASF1.
Potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk). Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively.
Packaging
Packaged under nitrogen.
5, 25 mg in glass bottle
Preparation Note
TG003 is soluble in DMSO at 33 mg/ml.
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :