TG003, >=98% (HPLC), solid

Not available outside of the UK & Ireland.

Application

TG003 has been used to develop assays for screening substances that affect mRNA splicing¹.

TG003 has been used in PAC1 cell culture and in vitro kinase assays.

Biochem/physiol Actions

TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.

TG003 regulates alternative splicing and reduces the phosphorylation of SF2/ASF1.

Potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk). K_i = 10 nM for mClk1/Sty; IC₅₀ = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively.

Packaging

Packaged under nitrogen.

5, 25 mg in glass bottle

Preparation Note

TG003 is soluble in DMSO at 33 mg/ml.