Verrucarine a de myrothepresso sp., >=98%( TLC)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Verrucarin A from Myrothecium sp has been used: as a translation initiation inhibitor in P. falciparum W2 strain as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cellsto test its cytotoxicity in renal cell carcinoma cells

Biochem/physiol Actions

Verrucarin A is phytotoxic to plantlet cultures and cytotoxic to cultured mammalian cell lines.

Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells

General description

Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound.

Other Notes

Macrocyclic trichothecene mycotoxin.