TDZD - 8,>= 98 %(HPLC) ,AIGUILLES

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Biochem/physiol Actions

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 µM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 µM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

Features and Benefits

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5, 25 mg in glass bottle

Preparation Note

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.