JW55, >=98% (HPLC)

Not available outside of the UK & Ireland.

Application

JW55 has been used as a tankyrase-specific inhibitor to study its effects on the transcriptional activity of SRY-related HMG-box gene 9 (Sox9) in chondrocytes.

Biochem/physiol Actions

JW55 is a potent and selective inhibitor of Wnt/β-catenin signaling, that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2) leading to stabilization of AXIN2 followed by increased degradation of β-catenin. JW55 specifically inhibits canonical Wnt signaling that results in reduced cell-cycle progression, proliferation, and colony formation in colon carcinoma cell lines.

JW55 can decrease the formation of mouse colon adenoma in vivo. It possesses a methoxyphenyl moiety spreading towards the G-loop.

Other Notes

JW55 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the JW55 probe summary on the Chemical Probes Portal website.

Packaging

5, 25 mg in glass bottle