CGP52432, > = 98%( HPLC)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

CGP52432 has been used as a γ-aminobutyric acid B (GABA_B) antagonist:to study its effects on the simulation of the onset of status epilepticus (SE) in micefor voltage-clamp recording in mice neuronsto study its effects on the GABA_B receptor-mediated neurotransmission in guinea pig hippocampus

Biochem/physiol Actions

CGP52432 participates in inhibiting the glycine overflow in the hippocampus.

CGP52432 is a very potent antagonist of GABA_B receptors. (IC₅₀ = 85 nM).

Features and Benefits

This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Do not freeze.

Packaging

5, 25 mg in glass bottle