LY-411575, > = 97 %(HPLC)

Code: SML0506-25MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.

Biochem/physiol Actions

LY-411575 is potent, cell perm...


 En savoir plus

Votre prix
$609.83 25MG
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.

Biochem/physiol Actions

LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. SML0506.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Packaging

5, 25 mg in glass bottle

assay≥97% (HPLC)
colorwhite to beige
formpowder
InChI keyULSSJYNJIZWPSB-CVRXJBIPSA-N
InChI1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1
Quality Level100
shipped inwet ice
SMILES stringC[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]2C(=O)N(C)c3ccccc3-c4ccccc24
solubilityDMSO: 5 mg/mL, clear
storage temp.−20°C
Cas Number209984-57-6
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN
GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.