Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
Elacridar has been used:as a chemical to decipher the link between autophagy and the mechanism of resistance to sunitinibas an ATP-binding cassette sub-family B member 1 inhibitor to study its effects on the NSC23766 cytotoxicityto treat rhodamine 123 (Rh123) labeled cells to set sorting gates in fluorescence-activated cell sorting (FACS)
Biochem/physiol Actions
GF120918 (Elacridar) is a very potent inhibitor of the ABC transporters MDR-1 (P-gp) and BCRP. GF120918 increases the bioavailability of cytotoxic anti-tumor drugs, and also leads to increased levels of anti-HIV drugs in the brain and CNS.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Packaging
10, 50 mg in glass bottle
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :