Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor: to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s) to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell linesto examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells
Biochem/physiol Actions
Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease.
S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.
Packaging
5, 25 mg in glass bottle
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