Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
SR 48692 has been used as a neurotensinhigh-affinity receptor 1 (NTSR1) antagonist: to explore the function of NTSR1 in glioblastoma (GBM) cells to determine the roles of neurotensin (NT) in the regulation of bile acid(BA) uptake, in vivo to explore the involvement of NTSR1 versus NTSR2 in mice
Biochem/physiol Actions
SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex.
Features and Benefits
This compound is featured on the Neurotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Packaging
5, 25 mg in glass bottle
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