BD 1063 dihydrochlorure, > = 98%( HPLC)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cellsin a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI)to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells

Biochem/physiol Actions

BD 1063 is a potent sigma(1) receptor antagonist; approximately 50-fold selective for sigma-1 over sigma-2 and 100-fold or more selective over 9 other tested neurotransmitter receptors. BD 1063 has been shown to antagonize cocaine efffects.

Other Notes

air sensitive

Packaging

5, 25 mg in glass bottle