VER-155008, >= 98%( HPLC )

Code: SML0271-5MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

VER-155008 has been used as a heat shock protein 70 (HSP70) inhibitor:to study its effects on human embryonic kidney 293 (HEK293T)cellsto study its effects on vir...


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Votre prix
$181.74 5MG
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

VER-155008 has been used as a heat shock protein 70 (HSP70) inhibitor:to study its effects on human embryonic kidney 293 (HEK293T)cellsto study its effects on viral mRNA synthesis and protein expression in Vero E6 cellsto determine its effects on the attenuation of seizures in rats

Biochem/physiol Actions

VER‐155008 positively promotes memory recovery and axonal regrowth. It is also involved in inhibiting cell cycle progression and proliferation in non-small-cell lung cancer (NSCLC).

VER-155002 is a small molecule, ATP-derivative inhibitor of HSP70 (IC50 = 500 nM). The compound inhibits proliferation of several colon and breast cancer cell lines, induces caspase dependent apoptosis in BT474 cells and down regulates expression of Her2 and Raf-1 in HCT116 cells.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to light brown
formpowder
InChI keyZXGGCBQORXDVTE-UMCMBGNQSA-N
InChI1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1
Quality Level100
SMILES stringNc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12
solubilityDMSO: >10 mg/mL
storage conditiondesiccated
storage temp.2-8°C
Cas Number1134156-31-2
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



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