S-15176 sel de difumarate, > = 98% ( HPLC), solide

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

The protonophoric activity of S-15176 difumarate salt was studied in mitochondria isolated from livers of Wistar rats.⁵

Biochem/physiol Actions

Antioxidant and anti-ischemic agent. Also inhibits mitochondrial permeability transition, prevents the early step in apoptosis by preventing collapse of the electrochemical gradient across the mitochondrial membrane. IC₅₀ for in vitro lipid peroxidation is 0.3 µM. IC₅₀ for carnitine palmitoyltransferase (CPT-1) in heart homogenate is 16.8 µM. The shift from fatty acid to glucose oxidation may contribute to anti-ischemic effect.

S-15176 suppresses the mitochondrial permeability transition in response to calcium ions and inorganic phosphate and inhibits the release of cytochrome c in response to silver ions. It exhibits weak protonophoric activity.⁵