SKA-31, >=98% (HPLC)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.

SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC₅₀ is almost identical at 2-3 µM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.

Packaging

5, 25 mg in glass bottle