Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
Photochemical reagent for the investigation of nucleic acid structure and function.
Psoralen has been used: as a crosslinker for dsRNA for in- situ hybridization studies in testing melanin dispersal effects in fish scale melanophores to test its stimulatory effects in osteoblast a cell proliferation assay as a reference standard in high-performance liquid chromatography (HPLC)
Biochem/physiol Actions
Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis
Features and Benefits
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Packaging
10, 25, 100 mg in glass bottle
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