Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
Phenamil methanesulfonate salt has been used: to stimulate adipocyte differentiation in 3T3 cells to test its effect on lateral flagella expression in Vibrio shiloniiin nanoparticle preparation to test its effect on osteo/odontoblastic differentiation
Biochem/physiol Actions
Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells.
General description
Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC).
Packaging
5, 25 mg in glass bottle
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