Acide okadaique provenant du concavum Prorocentrum, (HPLC), 92-100% (HPLC)

Code: O9381-.1MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Okadaic acid from Prorocentrum concavum has been used as a phosphatase inhibitor:to inhibit protein phosphatase 2 in spermatocytes cultureto treat SH-SY5...


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$1,231.77 EACH
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Okadaic acid from Prorocentrum concavum has been used as a phosphatase inhibitor:to inhibit protein phosphatase 2 in spermatocytes cultureto treat SH-SY5Y cells to prevent dephosphorylation to maintain tauto treat human embryonic kidney 293T cells (HEK293T) or H4 cells to analyse its effect on fused in sarcoma (FUS) protein

Biochem/physiol Actions

Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Okadaic acid is a polyether fatty acid. It is a marine toxin produced by the genera of ProrocentrumandDinophysis.

Preparation Note

Isolated from unialgal cultures of dinoflagellates.

assay92-100% (HPLC)
formpowder
InChI keyQNDVLZJODHBUFM-WFXQOWMNSA-N
InChI1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1
Quality Level200
SMILES stringO[C@@H](C[C@@H]([C@@]1([H])O[C@@]2(CCCCO2)CC[C@H]1C)C)[C@]3([H])C([C@@H](O)[C@]4([H])O[C@]5(CC[C@@](/C=C/[C@@H](C)[C@@]6([H])O[C@]7(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]7O)C=C(C)C6)([H])O5)CC[C@@]4([H])O3)=C
solubilityDMSO: ≥1 mg/mL, methanol: ≥1 mg/mL, ethanol: ≥1 mg/mL, H2O: insoluble
storage temp.−20°C
Cas Number78111-17-8
Hazard Class6.1
Un Number3462
Pack Group3
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