Hydrochlorure de mianserine,

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Mianserin hydrochloride has been used: as a reversible antagonist for serotonergic -protein coupled receptor (GPCR) - G-protein protein-coupled receptor (S7.1R)as an antidepressant in hippocampal astrocytes to test its effect on brain-derived neurotrophic factor(BDNF) mRNA expressionas a 5-hydroxytryptamine (5-HT) receptor antagonist to study its effect on serotonin modulation

Biochem/physiol Actions

Mianserin is a tetracyclic compound with sedative property. It lacks anticholinergic activity and is not effective on serotoninergic mechanisms. Mianserin is eliminated post biotransformation as hydroxylation, N-oxidation and N-demethylation products.

Antidepressant; antagonist/inverse agonist at 5-HT₂ serotonin receptors; also blocks the H₁ histamine receptor and the α₂ adrenoceptor.

Features and Benefits

This compound was developed by Organon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

1 g in poly bottle

100, 250 mg in poly bottle

Preparation Note

Solutions may be stored for several days at 4°C.