MRS 2578, >=95% (HPLC)

Not available outside of the UK & Ireland.

Application

MRS 2578 has been used an antagonist of purinoceptor P2Y6:to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine in P. aeruginosa infected mice to test its effect on the inflammatory responses to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes

Biochem/physiol Actions

MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.

Potent and irreversible antagonist of P2Y₆ nucleotide receptor.

Features and Benefits

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5, 25 mg in glass bottle