Jervine, >=98% (HPLC), powder

Code: j4145-1mg D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Jervine is a sonic hedgehog (Shh) pathway inhibitor.

Jervine is a potent teratogenic agent. It can induce apoptosis in leukemia cells and MUTZ-1...


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$203.28 1MG
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Not available outside of the UK & Ireland.

Biochem/physiol Actions

Jervine is a sonic hedgehog (Shh) pathway inhibitor.

Jervine is a potent teratogenic agent. It can induce apoptosis in leukemia cells and MUTZ-1 cells. Jervine is an inhibitor of Hedgehog signaling. It exhibits anti-cancer effects on human prostate cancer. It also increases the chemosensitivity of breast cancer cells to doxorubicin treatment. Jervine may be used for treating hypertension and heart disease.

General description

Jervine is a steroid alkaloid present in Veratrum californicum.

Packaging

1 mg in glass bottle

assay≥98% (HPLC)
formpowder
Gene Informationhuman ... EBP(10682)
InChI keyCLEXYFLHGFJONT-DNMILWOZSA-N
InChI1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1
Quality Level100
SMILES string[H][C@@]12C[C@H](C)CN[C@@]1([H])[C@@H](C)[C@@]3(CC[C@]4([H])C(=C3C)C(=O)[C@@]5([H])[C@@]4([H])CC=C6C[C@@H](O)CC[C@]56C)O2
solubilitymethanol: >2 mg/mL, H2O: insoluble
storage temp.−20°C
Cas Number469-59-0
Hazard Class6.1
Un Number2811
Pack Group3
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