17alpha-Hydroxyprogesterone, >=95%

Not available outside of the UK & Ireland.

Application

17α-Hydroxyprogesterone has been used: for titration against ovarian S9 protein in thin-layer chromatography as a substrate for hydroxysteroid dehydrogenase from B. megaterium culturesas a cortisone analog to test its effect on voltage-dependent potassium channels (Kv1)

Biochem/physiol Actions

17α-Hydroxyprogesterone (17OHP) is converted to 11-deoxycortisol in the presence of enzyme 21-hydroxylase. Deficiency of 21-hydroxylase results in the accumulation of 17OHP. High levels of 17OHP are observed in congenital adrenal hyperplasia (CAH).

General description

17α-Hydroxyprogesterone (17OHP) is a cortisol precursor and is synthesized from progesterone by the action of enzyme 17α-hydroxylase. 17OHP is a poor ligand for the nuclear progesterone receptor and an antagonist for mineralocorticoid receptor.

Packaging

5, 25 g in poly bottle