CHIC-35, >=97% (chiral, HPLC)

Code: C8742-1MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed is...


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$222.12 1MG
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 µM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

1, 5 mg in glass bottle

assay≥97% (chiral, HPLC)
formsolid
InChI keyABIVOOWWGYJNLV-JTQLQIEISA-N
InChI1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
Quality Level100
SMILES stringClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1
solubilityH2O: ﹤2 mg/mL, DMSO: >10 mg/mL
storage temp.2-8°C
Cas Number848193-72-6
Hazard Class6.1
Un Number2811
Pack Group3
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



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