N-(4-Bromophenyl) -3 -[ ( 4- bromophenyl) amino]sulfonyl] benzamide,>=98%( HPLC ),solide

Code: B3436-5MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Hunti...


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$238.28 5MG
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Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.

assay≥98% (HPLC)
coloroff-white
formsolid
InChI keySJJKUNDBFWUAQB-UHFFFAOYSA-N
InChI1S/C19H14Br2N2O3S/c20-14-4-8-16(9-5-14)22-19(24)13-2-1-3-18(12-13)27(25,26)23-17-10-6-15(21)7-11-17/h1-12,23H,(H,22,24)
Quality Level100
SMILES stringBrc1ccc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3ccc(Br)cc3)cc1
solubilityH2O: insoluble, DMSO: ~20 mg/mL
storage temp.2-8°C
Cas Number300670-16-0
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



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