AM281, >=98% (HPLC)

Not available outside of the UK & Ireland.

Application

AM281 has been used as a cannabinoid 1 receptor antagonist:to study its effects on memory deficit following naloxone-precipitated morphine withdrawal in miceto study the role of CB1 receptor system in modulating acetaldehyde-induced effects in rats during the extinction-, relapse-, and conflict-experimentsto study its effect on scopolamine-induced memory deficit using object recognition paradigmto block synthetic cannabinoid (HU210)-induced analgesia in the ventrolateral orbital cortex (VLO) to evaluate the effect of CB1 receptors on the VLO modulation of pain

Biochem/physiol Actions

Potent and selective CB₁ cannabinoid receptor antagonist/inverse agonist

AM281 is less lipophilic compared to its analog SR 141716A, a cannabinoid receptor antagonist. AM281 may prevent memory deficit post morphine withdrawal by inhibiting cannabinoid receptors in mice.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

10, 50 mg in glass bottle