Monoclonal anti-dnmt2

Not available outside of the UK & Ireland.

Biochem/physiol Actions

DNA methyltransferase 2 (DNMT2) might be involved in de novo methylation of newly integrated retroviral DNA in mammalian DNA. DNMT2 functions as a tRNA methyltransferase in lower eukaryotes. DNMT2 plays an essential role in zebrafish development by enhancing cytoplasmic RNA methylation. DNMT2 promotes DNA methylation in Drosophila.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq)

Immunogen

DNMT2 (AAH47733, 1 a.a. ~ 391 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFHHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLYILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVEEKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE

Legal Information

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Physical form

Solution in phosphate buffered saline, pH 7.4