Anti-phospho-TYK2 (pTyr1054) antibody produced in rabbit, affinity isolated antibody

Not available outside of the UK & Ireland.

Disclaimer

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Features and Benefits

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Immunogen

Peptide sequence around phosphorylation site of tyrosine 1054 (H-E-Y(p)-Y-R), according to the protein TYK2.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.