Anti-MAFF (N-terminal) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-MAFF (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F (MAFF) has been shown to interact with other transcription factors and it associates with certain regulatory sequences in the gene encoding the oxytocin receptor.

The three small Maf proteins participates in development, differentiation, hematopoiesis and stress response.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F (MAFF) is a transcription factor which does not have a transactivation domain but possesses a leucine-zipper.

Anti-MAFF (N-terminal) is developed in rabbit using a synthetic peptide corresponding to amino acids of human MAFF, conjugated to keyhole limpet hemocyanin (KLH) via a C-terminal added cysteine residue, as immunogen. The Maf family is divided into two subclasses, large Mafs (vMaf, cMaf, MafB and Nrl) and small Mafs (MafF, MafK, and MafG). Human MAF bZIP transcription factor F (MAFF) encodes a 164 amino acids protein. It lacks an N-terminal transactivating domain.

Immunogen

synthetic peptide corresponding to amino acids 2-17 of human MAFF, conjugated to KLH via a C-terminal added cysteine residue. The mouse and rat sequences differ from the human by one and two amino acids, respectively. Seven amino acids are identical in MaFG in the C-terminal region of the peptide.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, and 15 mM sodium azide.