Anticorps Monoclonal Anti - SHC4 produit dans la souris, clone 2F5, immunoglobulin purifiée, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

SHC (Src homology 2 domain containing) family member 4 (SHC4) has a role in cell migration and growth of metastatic melanomas. It is a substrate of the insulin-like growth factor 1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR). SHC4 associates with tropomyosin receptor kinase B (TrkB) and regulates the activation of mitogen-activated protein kinase (MAPK).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

SHC (Src homology 2 domain containing) family member 4 (SHC4) is a 69kDa protein expressed in melanomas. The gene encoding it is localized on human chromosome 15q21.1-q21.2.

Immunogen

SHC4 (AAH33907, 1 a.a. ~ 630 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGDKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVEFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEVHIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRGTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPALLHSNK

Legal Information

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Physical form

Solution in phosphate buffered saline, pH 7.4