Anticorps Monoclonal Anti - UBE2U produit dans la souris, clone 3D4, immunoglobulin purifiée, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

UBE2U (Ubiquitin-conjugating enzyme E2U) plays a vital role in the formation of E2-RING E3 network in the human ubiquitin-proteasome system. It acts as a hub protein in direct interaction with E3 ligase, MDM2. It links and holds E2-E3 network together for the ubiquitination activity, which finally transfer the ubiquitin to the E3-bound substrate. The protein also plays a role in the protein degradation process of misfolded and short-lived proteins.

General description

UBE2U (Ubiquitin-conjugating enzyme E2U) is an E2 enzyme belonging to the class III group of UbcH5 family of highly homologous E2s family. It consists of an extended C-terminal tail region attached to its UBC-fold. Its mRNA expression has been reported in the urogenital tract.

Immunogen

UBE2U (NP_689702.1, 9 a.a. ~ 102 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceLHRDFCDLKENNYKGITAKPVSEDMMEWEVEIEGLQNSVWQGLVFQLTIHFTSEYNYAPPVVKFITIPFHPNVDPHTGQPCIDFLDNPEKWNTN

Legal Information

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Physical form

Solution in phosphate buffered saline, pH 7.4