Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
TNS4 (Tensin 4) is mainly involved in cell migration activity. It exhibits oncogenic property in colonic, breast, lung, and gastric cancers. In studies, its overexpression has been reported in the pancreatic cancer cells. In pancreatic cancer cells, TNS4 promotes colony formation and cell motility. It has been predicted that TNS4 could be a prognostic marker for primary melanoma.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
TNS4 (Tensin 4) is a signaling molecule localized in the prostate and placenta. It is a member of the TENSIN gene family. It has a Src homology 2 and phosphotyrosine-binding domains. Its expression has been observed in the early progression of melanoma cells.
Immunogen
TNS4 (AAH18706, 1 a.a. ~ 480 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMGSKASSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQAPRNPTLTMGQPRTPHSPPLAKEHASSCPPSITNSMVDIPIVLINGCPEPGSSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQRELGGADGASDSTDSPASCQKKSAGCHTLYLSSVSVETLTGALAVQKAISTTFERDILPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRKWQKYCKPSWIFGFVAKSQTEPQENVCHLFAEYDMVQPASQVIGLVTALLQDAERM
Legal Information
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Physical form
Solution in phosphate buffered saline, pH 7.4
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