Anticorps Monoclonal Anti - CD48 produit dans la souris, clone MEM - 102, immunoglobulin purifiée, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 µg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Cluster of differentiation 48 (CD48) acts as an adhesion and co-stimulatory molecule and stimulates various effects in B and T lymphocytes, natural killer cells, mast cells and eosinophils. CD48 interacts with its ligand CD2 and other molecules and promotes rearrangement of signaling factors in lipid rafts, Lck-kinase activity and tyrosine phosphorylation.

Features and Benefits

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General description

The antibody MEM-102 reacts with CD48 antigen (Blast-1), a 40-47 kDa GPI-anchored membrane protein (immunoglobulin supergene family) widely expressed on hematopoietic cells; it is negative on granulocytes, platelets and erythrocytes.

Cluster of differentiation 48 (CD48) molecule, also known as BLAST1, is encoded by the gene mapped to human chromosome 1q23.3. CD48 is a glycosyl-phosphatidyl-inositol (GPI)-anchored cell-surface protein of immunoglobulin superfamily. The encoded protein is expressed on various hematopoietic cells.

Immunogen

Raji human Burkitt′s lymphoma cell line

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.