Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
CD22 (cluster of differentiation 22) helps to maintain B-cell homeostasis. This molecule act as an inhibitory coreceptor of the BCR (B cell receptor). CD22 is considered as a response regulator to control several aspects of B cell functions. Deficiency in CD22 or its pathways may contribute to autoimmunity.
Features and Benefits
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General description
CD22 (cluster of differentiation 22) is a 140kDa single-spanning membrane glycoprotein present on the surface of B cells. This gene belongs to the sialic acid-binding Ig-type lectin (Siglec) family. CD22 is mapped to human chromosome 19q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human BL-CAM around the phosphorylation site of Tyr807.Immunogen Range: 776-825
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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