Hélicoïdal Anti - phospho - Werner (pSer1141) produit en lapin ,environ 1 mg/mL, anticorps isolé affinité, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Werner syndrome, RecQ helicase-like (WRN) can interact with DNA polymerase δ (POLD1) and replication protein A (RPA) that are essential for the replication and repair of DNA. It also interacts with Ku protein which participates in double-strand DNA break repair. Mutation of the WRN gene results in Werner syndrome. WRN is a mortal target for cancer cells with microsatellite instability (MSI).

Disclaimer

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Features and Benefits

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General description

Werner syndrome, RecQ helicase-like (WRN) protein belongs to the RecQ family of DNA helicases. It has an adenosine triphosphate (ATP) binding site, one DExH helicase box, one exonuclease domain, and a nuclear localization signal. It is predominantly located in the nucleus. The WRN gene is located on human chromosome 8p12.

Immunogen

The antiserum was produced against synthesized peptide derived from human Werner Syndrome Helicase around the phosphorylation site of Ser1141.Immunogen Range: 1107-1156

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.