Anticorps Anti - MED24 C - Terminal produit en lapin, environ 1 mg / mL, anticorps isolé affinité, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-MED24, C-Terminal antibody produced in rabbit has been used in immunohistochemistry.

Biochem/physiol Actions

Mediator complex subunit 24 (MED24)/ thyroid hormone receptor associated protein 100 (TRAP100), which is a subunit of TRAP coactivator complex, might promote TRAP-mediated enhancement of nuclear receptor - signaling pathways. The MED1/MED24 complex plays an essential role in the pubertal mammary gland development and growth of breast carcinoma cells via the rat sarcoma (RAS)-mitogen-activated protein kinase (MAPK) pathway. The MED1/MED24 complex is over-expressed in female breast cancer (FBC). In Drosophila, mutation of gene encoding MED24 inhibit salivary gland cell death, caspase activation, and the breakdown of nuclear lamins.

Disclaimer

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Features and Benefits

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General description

Mediator complex subunit 24 (MED24), also known as thyroid hormone receptor associated protein 100 (TRAP100), is encoded by the gene mapped to human chromosome 17q21.1. The protein is ubiquitously expressed in human tissues, but at high level in skeletal muscle, heart, and placenta. TRAP100 is characterized with a notional zinc finger at N-terminal, a putative ATP/GTP binding site in the central region, and six dispersed LXXLL motifs.

Immunogen

The antiserum was produced against synthesized peptide derived from human MED24.Immunogen Range: 801-850

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.