Anti-synucléine - alpha,anticorps C - Terminal produit en lapin, environ 1 mg/ mL, anticorps isolé affinité, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Accumulation of α-synuclein in oligodendrocytes results in the loss of myelin and causes neurodegeneration, leading to multiple system atrophy. Synuclein-α is known to induce oligodendrocyte maturation. The encoded protein is considered to be an important aggregate of Lewy bodies, contributing to the pathogenesis of Parkinson disease.

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General description

Anti-Synuclein-α antibody detects endogenous levels of total Synuclein-α protein.

The SNCA (synuclein α) gene is mapped to human chromosome 4q22.1.

Immunogen

The antiserum was produced against synthesized peptide derived from human Synuclein-alpha.Immunogen Range: 86-135

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.