Anti-NOTCH4 (clavé -Val1432), anticorps C - Terminal produit en lapin, environ 1 mg / mL, anticorps isolé affinité, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

The NOTCH4 gene is associated with the process of angiogenesis and homeostasis during developmental process. NOTCH4 plays a role in Notch signaling pathway which mediates epithelial cell and stem cell homeostasis. Notch signaling pathway is induced in a number of cancer types including colon, breast, pancreatic, cervical, head and neck, renal carcinoma, prostate cancer, Large-cell and Hodgkin lymphomas.Thus, NOTCH4 is known to participate in tumorigenesis. This gene is involved in the development of central nervous system and controls neuronal maturation. Mutations in the gene might be associated with schizophrenia.

Disclaimer

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Features and Benefits

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General description

The NOTCH4 gene is mapped to human chromosome 6p21.32.

Anti-NOTCH4 (Cleaved-Val¹⁴³²) antibody detects endogenous levels of fragment of activated NOTCH4 (Cleaved-Val¹⁴³²) protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human NOTCH4.Immunogen Range: 1401-1450

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.