Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
Anti-NRF2, C-Terminal antibody produced in rabbit has been used in western blotting analysis.
Biochem/physiol Actions
Nrf2 (nuclear factor, erythroid 2 like 2) is involved in the regulation of anti-oxidative and anti-inflammatory response. The protein encoded is a transcription factor that binds to the antioxidant response element of the target gene. In response to oxidative stress, Nrf2 upregulates the enzymes associated with detoxification, anti-inflammation, cytoprotection and antioxidative pathways. Nrf2 affects glucose metabolism and ROS (reactive oxygen species) homeostasis in cancer cells by regulating the pentose phosphate pathway. Thus, Nrf2 is known to contribute to the development of cancer by promoting cell proliferation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Anti-NRF2 Antibody detects endogenous levels of total NRF2 protein.
NRF2 (nuclear factor, erythroid 2 like 2) gene is mapped to human chromosome 2q31.2. The encoded protein is localized to dendritic cells. It belongs to the cap ′n′ collar (CNC) family of transcription factors.
Immunogen
The antiserum was produced against synthesized peptide derived from human Nrf2.Immunogen Range: 556-605
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :