Anticorps Anti- Postn produit dans un anticorps isolé rabbit affinity

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-POSTN antibody produced in rabbit has been used in western blot.

Biochem/physiol Actions

Periostin (POSTN) facilitates extracellular matrix structure and organization. It acts as a collagen chaperone and regulates type I collagen fibrillogenesis. POSTN is implicated in early stages of bone formation, tissue repair, and cell recruitment and adhesion. This protein is essential for cancer stem cell maintenance and metastasis. Increased expression of POSTN has been observed in various types of cancers including prostate, breast, lung, pancreatic, ovarian, and colorectal cancer. Hence, the postn levels can be used as a prognostic biomarker for these cancers.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Periostin (POSTN) gene with 23 exons spanning 36 kb is mapped to chromosome 13q13.3. The gene codes for periostin, a matricellular protein that belongs to the family of non-structural matrix proteins. Periostin structure contains a signal peptide, four fasciclin-like domains (FAS1) with vitamin K-dependent γ-carboxyglutamic acid (Gla) residues, and hydrophilic C-terminal region with the heparin-binding site. The protein is mainly expressed in the periosteum, periodontal ligament, heart valves, and tendons. The antibody detects endogenous level of total periostin protein.

Immunogen

Peptide sequence around aa. 125-129 ( R-E-E-I-E), according to the protein NP_006466.2

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.