Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Vimentin helps to preserve the structure of cell and stability of tissue in mesenchymal cells. It is involved in tumorigenesis, EMT (epithelial mesenchymal transition) and the metastatic spread of cancer. It also controls infectious internalization of human papillomavirus 16 pseudovirions.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Vimentin is a specific type III intermediate filament (IF) protein. It is abundantly expressed in mesenchymal cells. It is located on human chromosome 10p13.The antibody detects endogenous level of total Vimentin protein.
Immunogen
Peptide sequence around aa. 452-456 (G-Q-V-I-N), according to the protein NP_003371.2
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Target description
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.
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