Anticorps Anti - ème (Ab - 31) produit dans un anticorps isolé rabbit affinity

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Th (tyrosine hydroxylase) plays an important role in catecholamine synthesis as it helps in the hydroxylation of L-tyrosine to l-DOPA (l-3,4-dihydroxyphenylalanine). Th gene mutation results in tyrosine hydroxylase deficiency.

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General description

Th (tyrosine hydroxylase) is a homotetramer that has regulatory, catalytic and tetramerization domains. The gene is located on chromosome llpl5.The antibody detects endogenous levels of total Tyrosine Hydroxylase protein.

Immunogen

Peptide sequence around aa. 29-33 (V-T-S-P-R), according to the protein NP_954986.2

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regulatory and catalytic domain, and exists in several different isoforms . This enzyme is required for embryonic development since TH knockout mice die before or at birth . Levels of transcription, translation and posttranslational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH . Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels.