Anticorps Anti - OPRM1 (Ab - 375) produit dans un anticorps isolé rabbit affinity

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-OPRM1 (Ab-375) antibody produced in rabbit has been used in Western blotting.

Biochem/physiol Actions

The gene OPRM1 (opioid receptor μ 1) encodes a μ opioid receptor that functions in pain perception and addiction to drugs of abuse, such as cocaine, nicotine and alcohol. It serves as a target for opioid drugs, such as morphine, methadone and heroin and opioid peptides (like β - endorphin and endomorphins) and mediates their effects. Single nucleotide polymorphism in the OPRM1 gene is associated with an inclination to drug addiction and lesser response to painful stimuli.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

The gene OPRM1 (opioid receptor μ 1) is mapped to human chromosome 6q24-q25. The gene spans a length of 200kb and contains 11 exons that yield 17 splice variants.

Immunogen

Peptide sequence around aa. 373-377 (H-P-S-T-A), according to the protein OPRM1.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.