Anti-NFKB1 (Ab-927) antibody produced in rabbit, affinity isolated antibody

Not available outside of the UK & Ireland.

Biochem/physiol Actions

NFKB1 (nuclear factor κB subunit 1) controls the maturation of NK (natural killer) cells and effector functions. It helps in the upregulation of intrauterine adhesion inflammatory factors, hence it plays a major role in inflammatory diseases.

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General description

NFKB1(nuclear factor κB subunit 1) is a dimeric transcription factor. It belongs to the REL family. It is located on chromosome 4q24.

Immunogen

Peptide sequence around aa. 925-929 (C-D-S-G-V ), according to the protein NFKB1.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.