Anti-PRKD1 (Ab-910) antibody produced in rabbit, affinity isolated antibody

Not available outside of the UK & Ireland.

Biochem/physiol Actions

PRKD1 (Protein kinase D 1) is a negative modulator of cell migration . It plays an important role in cell adhesion, cell migration, vesicle transport, cell survival , signal transduction, membrane trafficking and immune function. It preserves the epithelial phenotype by inhibiting epithelial-to-mesenchymal transition.

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General description

PRKD1 gene encodes PKD1 (protein kinase D1), that belongs to the protein kinase D family. It is a serine/threonine kinase, which is expressed in cells of the normal mammary gland. The PRKD1 gene promoter has a great CpG island covering 1.2kb, including the transcription start site and the entire exon 1.

Immunogen

Peptide sequence around aa. 908-912 (R-V-S-I-L), according to the protein PRKD1.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress through activation of NF-kappa-B.