Anticorps phospho-STAT3 (pTyr705) produit dans un anticorps isolé rabbit affinity

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-phospho-STAT3 (pTyr705) antibody produced in rabbit has been used in immunohistochemical staining and immunoblotting.

Biochem/physiol Actions

Signal transducer and activator of transcription 3 (STAT3) plays a vital role in various cellular responses such as induction of an acute-phase response in hepatoma cells, stimulation of proliferation in B lymphocytes, activation of terminal differentiation and growth arrest in monocytes, and regulation of the pluripotency of embryonic stem cells. Activated STAT3 has been involved in malignant transformation. STAT3 may be a key player in the pathogenesis of diverse human cancers which makes this molecule a prime target for novel therapies. Phospho-tyrosine residue 705 (Tyr705) Stat3 can be used as a potential marker for determining overall survival of node-negative breast cancer patients. Phosphorylated STAT3 might be involved in angiogenesis, anti-apoptosis and tumor progression.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Signal transducer and activator of transcription 3 (STAT3) is a member of STAT family and it composed of 770 amino acids. The gene encoding protein consists of 24 exons and is extended over a length of 75170 bases on genomic DNA STAT3 is mapped on human chromosome 17q21.2. The protein is characterized with a conserved amino-terminal domain, a DNA-binding domain, an SH2 domain and a carboxy-terminal transactivation domain.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 705 (A-P-Y(p)-L-K), according to the protein STAT3.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.