Anticorps Anti - TRIM2 produit en lapin, environ 1,5 mg/mL

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-TRIM2 antibody produced in rabbit in immunoblotting and western blotting.

Anti-TRIM2 antibody produced in rabbit has been used in western blot analysis.

Biochem/physiol Actions

Tripartite motif-containing protein (TRIM) RING finger proteins play an important role in cancerogenesis and in defense against viral infection. Mutations in the RING finger protein Parkin is associated with Parkinson′s disease (PD), and translocation of the TRIM gene is linked to acute promyelocytic leukemia. TRIM2 plays an important role in regulating neurofilament (NF-L) metabolism.

Tripartite motif containing 2 (TRIM2) ubiquitinates neurofilament light chain, B-cell lymphoma 2 (Bcl-2)-interacting mediator and motor protein myosin V. It has a role in polarization of neurons and outgrowth of axons. Loss of function of the protein has been linked to early-onset axonal neuropathy.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Tripartite motif-containing protein 2 (TRIM2), also known as RNF86, Narf is highly expressed in the nervous system.

Tripartite motif containing 2 (TRIM2) is an E3 ubiquitin ligase, encoded by the gene mapped to human chromosome 4q31.3. The encoded protein belongs to the TRIM– NCL-1, HT2A and Lin-41 (NHL) protein family. This 81kDa protein is characterized with an N-terminal really interesting new gene (RING) finger domain and a B-box domain, a middle coiled-coil domain and a C-terminal NHL domain.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.