Anticorps Anti - POU1F1 / PIT1 produit en lapin, environ 1,0 mg / mL, anticorps isolé affinité, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-POU1F1/PIT1 antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

Pituitary-specific positive transcription factor 1 (POU1F1/PIT1) is responsible for pituitary development and hormone expression in mammals. It regulates mammalian development. POU1F1/PIT1 is required for the differentiation and proliferation of the anterior pituitary somatotrophs, lactotrophs and thyrotrophs cell lineages. Mutation in Pit-1 gene is associated with the syndrome of combined pituitary hormone deficiency (CPHD), a disease characterized by the lack of prolactin, growth hormone and thyroid stimulating hormone β. POU1F1/PIT1 regulates its target gene expression by binding to response elements on their promoter regions and recruitment of co-regulatory proteins, that alter histone acetylation and modify chromatin structures.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Pituitary-specific positive transcription factor 1 (POU1F1/PIT1) is a pituitary-specific transcription factor and is a member of the POU family of transcription factors.

POU1F1 is encoded by the gene mapped to human chromosome 3p11.2.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Specificity

Anti-POU1F1/PIT1 recognizes human POU1F1/PIT1.

Storage and Stability

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.