ANTI-hélamlutinine monoclonale

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Hemagglutinin (HA), specially HA2 is responsible for the binding of the virus to host receptors and enables its entry into the host cell through endocytosis through endosomal membrane fusion. HA is the primary target for neutralizing antibodies. HA is a potent target for drug and vaccine development.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Hemagglutinin [Influenza A virus (A/chicken/Jilin/9/ 2004(H5N1))] is the principal surface antigen of influenza A virus. Hemagglutinin (HA) is a homotrimer; each monomer is a single polypeptide (HA0) that is post transcriptionally cleaved by host proteases into two subunits (HA1 and HA2). HA2 is highly conserved across different strains of influenza virus. HA preferentially binds to α2-3 sialic acid receptor in aves, whereas in human it binds to α2-6 sialic acid receptor.

Immunogen

Antibody was raised against a peptide corresponding to 13 amino acids in the middle of the Hemagglutinin protein.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.