Anticorps Anti- TET2 produit en anticorps isolé rabbit affinity

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-TET2 antibody produced in rabbit has been used in Western blotting.

Biochem/physiol Actions

Tet methylcytosine dioxygenase 2 (TET2) is involved in the conversion of 5-methylcytosine to 5-hydroxymethyl-cytosine (5hmC). It also has a role in stimulating DNA demethylation and lymphomagenesis. Mutations in the gene encoding TET2 have been linked to myelodysplastic syndromes.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Tet methylcytosine dioxygenase 2 (TET2) is part of the Fe(II)/α-ketoglutarate-dependent dioxygenase family of enzymes. It is expressed in the brain. The gene encoding TET2 is localized on human chromosome 4q24.

Immunogen

Antibody was raised against an 18 amino acid peptide near the amino terminus of human TET2.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500711.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.