Anticorps Anti - Bax produit dans le lapin, fraction IgG d' antisérum, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-Bax antibody produced in rabbit has been used in Western blotting.

Biochem/physiol Actions

BCL2 associated X, apoptosis regulator (BAX) forms a heterodimer with B-cell lymphoma 2 (BCL2) and functions as an apoptotic activator. BAX interacts with and increases the opening of the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in the mitochondrial membrane potential and the release of cytochrome c. The expression of BAX gene is regulated by the tumor suppressor p53 and BAX has been shown to be involved in p53-mediated apoptosis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

BCL2 associated X, apoptosis regulator (BAX) is a proapoptotic protein of the B-cell lymphoma 2 (BCL2) protein family. The gene encoding it is localized on human chromosome 19q13.33.

Immunogen

Bax antibody was raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Bax.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500343.

Physical form

Supplied in PBS with 0.02% sodium azide.